The present invention relates to a medicament delivery device (10) comprising: a cartridge holder (14) mounted in a housing (11) and configured to receive a cartridge (15) containing a medicament, the housing (11) having a longitudinal axis (X) an outer cap (69) detachably connected to the housing (11) and a coupling mechanism (18)configured to connect the outer cap (69) to an injection needle holder (39) to which an injection needle (17) is fixed, the injection needle (17) having a proximal end (42) and a distal end (43). The coupling mechanism (18) comprises a rotatable member (63) which is configured to be connected to an injection needle holder (39) and which is threadedly engaged with the outer cap (69) and is rotatable relative to the outer cap, and wherein the coupling mechanism (18) is configured such that pulling the outer cap (69) away from the cartridge holder (14) in a first axial direction along the longitudinal axis (X) causes rotational movement of the rotatable member (63) and thereby of an injection needle holder (39) connected thereto, about the longitudinal axis (X) and translational movement of the rotatable member (63) and thereby a connected injection needle holder (39) relative to the housing (11) in a second axial direction opposed to the first axial direction such that the injection needle holder (39) moves from a storage position in which, when the cartridge (15) is received in the cartridge holder (14), the distal end (43) of the injection needle (17) is spaced from the cartridge (15), towards a use position in which, when the cartridge (15) is received in the cartridge holder (14), the distal end (43) of the injection needle (17) can engage the cartridge (15).La présente invention concerne un dispositif dadministration de médicament (10) comprenant : un support de cartouche (14) monté dans un boîtier (11) et conçu pour recevoir une cartouche (15) contenant un médicament, le boîtier (11) ayant un axe longitudinal (X) un bouchon externe (6
