Patricia D. Palena,Richard R. Barto, Jr.,Tammie L. Borders,Jeffrey A. Stuart
申请号：
US12348128
公开号：
US08236243B2
申请日:
2009.01.02
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A nano-structured device for detecting biological analytes, chemical, analytes, cancer and other physiological conditions, includes a carrier substrate, a transducer film disposed over a surface of the carrier substrate, and a dendrimer structure tethered to the transducer film. The transducer film generates a first signal in response to a mechanical stress applied thereto. The first signal indicates the detection of the biological analyte, chemical analyte, cancer or other physiological condition. The dendrimer structure includes a plurality of receptors for binding the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological conditions to the dendrimer structure. The dendrimer structure applies the mechanical stress to the transducer film, which is proportional to the strain induced into the dendrimer by the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological condition binding to the receptors, the mechanical stress causing the transducer film to generate the first signal indicating the detection of the biological analyte, the chemical analyte, or one or more biomarkers indicative of cancer or other physiological condition.
