A medical device configured to be adhesively coupled to an external surface of a subject, and to facilitate physiological monitoring of the subject, includes: a first portion having a housing that at least partially encloses an interior chamber and has a grip portion that has a peanut-like shape; and a second portion including a flexible patch configured to facilitate operably coupling the first portion to the subject. The flexible patch includes third and fourth sensor connections configured to operably interface with the first and second sensor connections, respectively; first and second sensing elements; and a flexible circuit assembly configured to electrically couple the third sensor connection to the first sensing element and the fourth sensor connection to the second sensing element. An adhesive assembly is configured to couple the first portion to the second portion, and includes conductive adhesive portions.