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MRI CONTRAST AGENT CONTAINING COMPOSITE PARTICLES
专利权人:
Yoshiyuki Tago
发明人:
Yoshiyuki Tago,Shinichi Yoshida,Kohji Ohno,Yoshinobu Tsujii,Yasuhiko Tabata
申请号:
US13991050
公开号:
US20130251636A1
申请日:
2011.09.29
申请国别(地区):
US
年份:
2013
代理人:
摘要:
Intended is to provide an MRI contrast agent that tends not to be phagocytized by reticuloendothelial cells and that has improved dispersion stability. The present invention is an MRI contrast agent containing composite particles, wherein the composite particles are those with polymer graft chains bound to surfaces of microparticles at a very high density sufficient to allow steric repulsion to occur between the graft chains, the micoparticles are inorganic microparticles that exhibit superparamagnetism, and the polymer graft chains have a number average molecular weight (Mn) of at least 30,000. Preferably, the MRI contrast agent is for tumor diagnosis.
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中国工程科技知识中心
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