COMBINATIONS COMPRISING A VASCULOSTATIC COMPOUND AND AN EPOTHILONE DERIVATIVE AND USE THEREOF IN THE PREPARATION OF MEDICAMENTS FOR THE TREATMENT OF PROLIFERATIVE DISEASES AND DISEASES ASSOCIATED WITH DEREGULATED ANGIOGENESIS
The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NR N , wherein R N is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond, in which the active ingredients (a) and (b) are present in each case in free form or in the form of a pharmaceutically acceptable salt and optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease, especially a solid tumor disease； a pharmaceutical composition, a commercial package or product comprising such a combination； the use of such a combination for the preparation of a medicament for the delay of progression or treatment of a proliferative disease and to a method of treatment of a warm-blooded animal.
