High-affinity TCR for NY-ESO

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专利权人:

Ltd.;Guangdong Xiangxue Life Sciences

发明人:

Li, Yi,Huang, Jinhua

申请号：

AU2017370264

公开号：

AU2017370264A1

申请日:

2017.11.29

申请国别(地区):

AU

年份:

2019

代理人:

摘要：

Provided is a T cell receptor (TCR) having a property of binding to a SLLMWITQC-HLA A2 complex； and the binding affinity of the TCR to the SLLMWITQC-HLA A2 complex is at least twice that of a wild-type TCR to the SLLMWITQC-HLA A2 complex. Also provided is a fusion molecule of such a TCR with a therapeutic agent. Such a TCR can be used alone or in combination with a therapeutic agent so as to target tumour cells presenting the SLLMWITQC-HLA A2 complex.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/