Bannen, Lynne Canne,Chen, Jeff,Forsyth, Timothy Patrick,Jammalamadaka, Vasu,Leahy, James William,Mann, Grace,Nuss, John M.,Takeuchi, Craig Stacy,Xu, Wei,Chan, Diva Sze-Ming,Dalrymple, Lisa Esther,Huyn
申请号：
AU2010204461
公开号：
AU2010204461B2
申请日:
2010.07.27
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2010204461B220130620.pdf#####C NRPonbl DCC JAM087142_I.DOC-26f7/2()10 ABSTRACT The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed 5 cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. 10 The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
