PROBLEM TO BE SOLVED: To provide a new preparation for the treatment of diseases relating to gastric acid.SOLUTION: The pharmaceutical composition to be administered orally in a solid form for the treatment of diseases relating to gastric acid contains (i) a certain amount of at least one specific acid-sensitive substituted benzimidazole H+, K+-ATPase proton pump inhibitor devoid of enteric coating, (ii) a buffering agent containing sodium bicarbonate in an amount sufficient to protect the proton pump inhibitor of the above amount against acid degradation with gastric acid after oral administration and (iii) a disintegrating agent.COPYRIGHT: (C)2008,JPO&INPIT【課題】胃酸関連疾患の治療の新規な製剤の提供。【解決手段】胃酸関連疾患の治療のために経口投与される固体投与形の医薬組成物であって、(i)或る量の、少なくとも1種の腸溶性被覆されていない特定の酸感受性置換ベンゾイミダゾールH+,K+-ATPアーゼプロトンポンプ阻害剤;(ii)前記の量の前記プロトンポンプ阻害剤を、経口投与後に胃酸による酸分解から保護するのに十分な量の重炭酸ナトリウムを含む緩衝剤;及び(iii )崩壊剤、を含んでなる医薬組成物。【選択図】なし
