Shannon S. Stahl,Samuel H. Gellman,Sarah E. Lee,Mehmet F. IIker,Bernard Weisblum,Denis Kissounko
申请号：
US14804619
公开号：
US20150322205A1
申请日:
2015.07.21
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
