University of New Orleans;University of Pittsburgh - Of the Commonwealth System of Higher Education;Board of Supervisors of Louisiana State University and Agricultural and Mechanical College
发明人:
Jay Kennedy Kolls,Mingquan Michael Zheng,Yang Cai,Taylor John Eddens,David M. Ricks
申请号：
US15127383
公开号：
US20170173126A1
申请日:
2015.03.19
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of a sequenced genome has hindered antigen discovery that could be useful in developing effective vaccines, therapeutic antibodies and diagnostic methods. A method of surface proteomics of Pneumocystis murina that reliably detects surface proteins that are conserved in Pneumocystis jirovecii is described. In particular, eight identified P. murina surface proteins are described. Methods of eliciting immune responses against the identified proteins, generating therapeutic antibodies against the identified proteins, as well as diagnostic methods based on the identified peptides are described.
