A pharmaceutical composition comprising derhamnosylmasin or pharmaceutically acceptable salt thereof as an active ingredient for prevention and treatment of diabetes mellitus
The present invention relates to a pharmaceutical composition for preventing and treating diabetes comprising derhamnosylmasin or a pharmaceutically acceptable salt thereof as an active ingredient, and specifically relates to a pharmaceutical composition for treating or preventing diabetic dyslipidemia, As a result of confirming that diramnosylmecin is useful for the prevention and treatment of diabetes by confirming that it increases intracellular glucose uptake rate, increases PPARγ (peroxisome proliferator-activated receptor γ) activity and activates insulin signal transduction pathway have.본 발명은 디람노실메이신(derhamnosylmasin) 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 함유하는 당뇨병 예방 및 치료용 약학적 조성물에 관한 것으로, 구체적으로 디람노실메이신을 근육세포에 처리하여 그 효과를 확인한 결과, 세포 내 포도당 흡수율을 증가시키고, PPARγ(peroxisome proliferator-activated receptor γ)활성을 증가시키며, 인슐린 신호전달 경로를 활성화 시킴을 확인함으로써, 디람노실메이신은 당뇨병의 예방 및 치료에 유용하게 사용될 수 있다.
