PROBLEM TO BE SOLVED: To provide a compound which has excellent dUTPase-inhibiting activity and is useful as an anti-tumor agent, an efficacy potentiator for anti-tumor agents or the like.SOLUTION: The 5-fluorouracil compound is represented by general formula (I) (wherein n denotes a number of 1 to 3 X represents an oxygen atom, a sulfur atom, a 2-6C alkenylene group, or the like Y represents a 1-8C alkylene group Z represents -SO2NR1R2, -NR3SO2-R4 and the like R1 and R2 each represents a hydrogen atom, a 1-6C alkyl group or aralkyl group or a group forming a saturated heterocyclic group together with an adjacent nitrogen atom R3 represents a hydrogen atom or a 1-6C alkyl group R4 represents an aromatic hydrocarbon group or an unsaturated heterocyclic group and R5 represents a methyl group). Also the salt thereof is provided.COPYRIGHT: (C)2013,JPO&INPIT【課題】優れたdUTPase阻害活性を有し、抗腫瘍薬、抗腫瘍薬の効果増強剤等として有用な化合物の提供。【解決手段】一般式(I)(一般式(I)中、nは1~3の数を示し、Xは、酸素原子、硫黄原子、炭素数2~6のアルケニレン基等を示し、Yは、炭素数1~8のアルキレン基を示し、Zは、-SO2NR1R2、-NR3SO2-R4等を示し、R1及びR2は、水素原子、炭素数1~6のアルキル基又はアラルキル基を示すか、或いは隣接する窒素原子と一緒になって、飽和複素環基を形成する基を示し、R3は、水素原子又は炭素数1~6のアルキル基を示し、R4は、芳香族炭化水素基又は不飽和複素環基を示し、R5は、メチル基を示す。)で表される5-フルオロウラシル化合物又はその塩。【選択図】なし
