Covering pearls include: (a) granules； (b) the first layer is covered on granules, the first layer contains the first batch of active pharmaceutical ingredients, including stimulants of central nervous system； (c) the second layer is covered on the first layer； The second layer has enough content, which can greatly delay the release of the first layer of active medicinal materials until the pearl coating reaches a part of the gut of the object under management. And (d) the third layer is covered by the second layer,The third layer contains the second layer of active pharmaceutical ingredients, and the third layer of structure allows the immediate release of a large number of active pharmaceutical ingredients contained therein. In addition, an embodiment related to oral solid-state pharmaceutical ingredients is also adopted. Claim 3: pearl coating as defined in claim 2, which is characterized in that the internal coating released under control is selected from a group of substances composed of cellulose polymer, cellulose ether, polyethylene oxide, polyethylene derivative and methacrylic acid copolymer, polyethylene glycolPolyacrylic acid, polyacrylic acid, polyacrylic acid, polyacrylonitrile, poly (n-hydroxybutyric acid)2. Polyamine acid, polyamine；Polyester, vinyl acetate (EVA),1. Polyvinylpyridine (PVP),Acrylic (acrylic) ester (PAA),Methacrylic acid (PMAA) and any mixture of two or more. Claim 13: Pearl wrap as defined in claims 2-12, characterized by the delayed release of the outer coating selected from the guar rubber, patina, HPMC, cellulose acetate, cellulose trimethylacetate, a polyethylene group. Biodegradable, poly (metallic co metallic) 1:2, poly (metalechlic co metallic) 1:1, ftalato de vinyl acetate, azoebene de metalimiloiloxi, metaclato de 2-hydroxidi (HEMA),Dextrano's hydrogel and any two or more mixtures Claim 24: Pearl cladding as defined in claims 1-23, which is characterized by a fourth layer covering a third layer,The fourth layer contains at le
