MALININ, VLADIMIR,PERKINS, WALTER,LEIFER, FRANZISKA,KONICEK, DONNA,LI, ZHILI,PLAUNT, ADAM
申请号：
CA2927788
公开号：
CA2927788A1
申请日:
2014.10.24
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C5-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.
