A kind of device is used to save the substance based on liquid of predetermined close, especially animal semen, or saving medium includes embryo or tissue sample, including pipe (11) by the plastic material that welds. Pipe allows business, and wherein receiving portion (21) intends have circular cross-section comprising the predetermined close, and hermetic unit (22) includes welding constriction (19) and transition region (23). It distinguishes the visual appearance on the outer surface of fringe region (28) to outlet pipe at least part hermetic unit to be different from outside outer cylinder, the differentiation of edge region. Range includes such device and similar device, but without distinguishing edge region.