Adamski-Werner, Sara,Zoller, Mark,Fine, Richard,Tang, Xiao-Qing,Klebansky, Boris,Rinnova, Marketa,Karanewsky, Donald S.,Zlotnik, Albert,Servant, Guy,Fotsing, Joseph R.,Zhang, Hong,Tachdjian, Catherine
申请号：
AU2008262109
公开号：
AU2008262109B2
申请日:
2008.06.03
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
The present invention includes methods for identifying modifiers of chemosensoryreceptors and their ligands, e.g., by determining whether a test entity is suitableto interact with one or more interacting sites within the Venus flytrap domainsof the chemosensory receptors, and modifiers capable of modulating chemosensoryreceptors and their ligands. The present invention also includes modifiersof chemosensory receptors and their ligands having Formula (I), its subgenus,and specific compounds. Furthermore, the present invention includes ingestiblecompositions comprising the modifiers of chemosensory receptors and theirligands and methods of using the modifiers of chemosensory receptors and theirligands to enhance the sweet taste of an ingestible composition or treat a conditionassociated with a chemosensory receptor. In addition, the present inventioninclude processes for preparing the modifiers of chemosensory receptors andtheir ligands.
