Wang, Aijun,Datta, Deepshikha,McCraith, Stephen,Nairn, Natalie Winblade,Grabstein, Kenneth H.
申请号：
AU2013203486
公开号：
AU2013203486A1
申请日:
2013.04.10
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
#$%^&*AU2013203486A120130502.pdf#####ABSTRACT The invention provides compositions and methods of identifying, modifying and producing modified target molecules, including therapeutic molecules by modification with non-natural amino acids. Certain aspects of the invention include methods of adding a chemical moiety to a target molecule, and the compositions resulting therefrom. Certain aspects of the inventions also relate to kits for identifying, modifying and producing modified target molecules described herein.8/8 1000 1. 800 -- Vehicle 3x/wk 600 -- BS IOU 3x/week 10K PEG 10U 1x/wk 40 -- BS 1OU lxwk .2 400 p.001 S200. o 20 25 30 35 40 45 50 55 60 65 day post implant FIG. 8A 1000 800 --- Vehicle 600 - BS 1OU 3X/wk -- 2OK PEG 3U 1X/wk -B- 5104 IX/wk 400200 0 -0.020 25 30 35 40 45 50 55 60 65 Day post implant FIG. 8B
