Provided are methods of treating autoimmune diseases. The method entails administering to an individual in need of treatment one or more compositions that contain one or more inhibitors of histone deacetylatse (HDAC) and one or more inhibitors of BRD4. The method can include administering an inhibitor of binding of BRD4 to chromatin, an inhibitor of activation of BRD4 by phosphorylation, an inhibitor of signaling pathways leading to induction or increased expression of Type I interferon stimulated genes (ISG), and combinations thereof. The inhibitors may be administered at a sub-therapeutic dose, and may be administered concurrently or sequentially, in any combination.
