Method the present invention is provided to treat cancer (for example, B cell cancer, such as Hodgkin lymphoma or acute lymphoblastic leukemia), reduce its seriousness or it is inhibited to grow. The method of the present invention includes the antibody or its antigen-binding fragment in conjunction with programmed death 1 (PD-1) receptor-specific to required individual application therapeutically effective amount, combine with the bispecific antibody for being specifically bound to CD20 and CD3 of therapeutically effective amount.
