PURPOSE: A chewable tablet for oral administration, containing atomoxetine or a pharmaceutically acceptable salt thereof, a hydrophilic polymer, and an anionic polymer is provided to effectively block unpleasant taste (bitter taste, acrid taste) without a separate process or facility, and to enhance drug compliance.CONSTITUTION: A chewable atomoxetine tablet for oral administration contains 1 part by weight of atomoxetine or a pharmaceutically acceptable salt thereof, 0.01- 1 parts by weight of a hydrophilic polymer, and 0.1-10 parts by weight of an anionic polymer. The hydrophilic polymer is selected from the group consisting of gelatin, hydroxylpropyl methylcellulose, low viscosity hydroxylpropyl methylcellulose, hydroxylethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose, and polyvinyl alcohol. The anionic polymer is selected from the group consisting of carrageenan, chondroitin sulfate, dextran sulfate, alginic acid, sodium alginate, gerun gum, and xanthan gum.COPYRIGHT KIPO 2013[Reference numerals] (AA) Release rate (%) (BB) 0.1N HCI test solution (CC) Example 11 (DD) Time (minutes)본 발명은 불쾌한 맛을 효과적으로 차폐한 경구용 아토목세틴 츄어블 정제에 관한 것으로, 더욱 상세하게는 아토목세틴 또는 이의 약학적으로 허용가능한 염에 친수성 고분자 및 음이온성 고분자를 포함함으로써, 약물의 불쾌한 맛을 효과적으로 차폐하고, 구강 내에서 빠르게 녹여먹을 수 있는 후미개선 효과, 즉 환자의 복용 순응도를 높인 경구용 아토목세틴 츄어블 정제에 관한 것이다.
