The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use thereof for the production of medicinal products for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.本發明係關於新穎經取代環化嘧啶類,其製造方法,其單獨或組合用於治療及/或預防疾病之用途及其用於製造供治療及/或預防疾病之醫藥產品之用途,特別是用於治療及/或預防心血管疾病。