The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I):whereinRh and Rj are taken together to form a bond； Ra and Rb and/or Rd and Re are taken together to form oxo or the like； Rc is hydrogen, substituted or unsubstituted alkyl or the like；Rf is -(CR4aR4b)n-R2； R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like； R2 is substituted or unsubstituted cycloalkyl or the like； n is an integer of 1 to 4； -Rg is -X-R3； -X- is -O-, -S- or the like； R3 is substituted or unsubstituted cycloalkyl or the like,or its pharmaceutically acceptable salt or a solvate thereof.
