VARIANT ACTRIIB PROTEINS AND USES THEREOF

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专利权人:

ACCELERON PHARMA INC.

发明人:

KUMAR, RAVINDRA,GRINBERG, ASYA,VOGAN, ERIK M.

申请号：

CA3039525

公开号：

CA3039525A1

申请日:

2017.10.05

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of red blood cells or a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.

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