The United States of America, as represented by the Secretary, Department of Health and Human Services;Duke University;The University of North Carolina at Chapel Hill
发明人:
Stavros Garantziotis,John W. Hollingsworth,Bryan P. Toole,Jian Liu
申请号：
US14398837
公开号：
US09717752B2
申请日:
2013.03.08
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present disclosure provides a method of preventing or reducing AHR in a subject suffering from or at risk for AHR by administering a hyaluronan antagonist. Also provided is a method of treating an airway disease or disorder in a subject by administering a hyaluronan antagonist. Hyaluronan antagonists include, for example, heparosan and hyaluronan oligosaccharides (oHAs). In some embodiments, the hyaluronan antagonist is administered locally to the airway, such as with an inhaler or nebulizer.
