CRYSTALLINE FORMS OF 3-(IMIDAZO[1,2-B] PYRIDAZIN-3-YLETHYNYL)-4-M ETHYL-N-(4-[(4-METHYLPIPERAZIN-1-YL) METHYL]-3-(TRIFLUOROMETHYL)P HENYL)BENZAMIDE AND ITS MONO HYDROCHLORIDE SALT.
Christopher K. MURRAY,Leonard W. ROZAMUS,John J. CHABER,Pradeep SHARMA
申请号：
MX2015007578
公开号：
MX359147B
申请日:
2013.12.12
申请国别(地区):
MX
年份:
2018
代理人:
摘要：
Novel crystalline forms of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methy lpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyljbenzamide free base and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methyl piperazi n-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, pharmaceutical compositions thereof and methods of their preparation and use are disclosed herein. The instant application is directed to novel crystalline forms of 3-(imidazo[1,2-b] pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methylpiperazin-1-yl) methyl]-3-(trifluoromethyl}phenyl}benzamide and 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyi-N-{4-[(4-methy lpiperazin-1 -yl)methyl]-3-(trifluoromethyl)phenyl}benzamide mono hydrochloride, compositions comprising such crystalline forms, and to methods of their preparation and use.La presente describe formas cristalinas novedosas de la base libre de 3-(imidazo[1 ,2-b]piridazin-3-iletinil)-4-metil-N-(4-[(4- metilpiperazin-1-il)metil]-3-(trifluorometil)fenil)benzamida y monoclorhidrato de 3-(imidazo[1 ,2-b]piridazin-3-iletinil)-4-metil -N-(4-[(4-metilpiperazin-1-il)metil]-3-(trifluorometil)fenil)benz amida, sus composiciones farmacéuticas y métodos para su preparación y uso.
