The present invention relates to a method of treating psychiatric symptoms in a subject having a NMDA receptor and a NE receptor which includes administering d- methadone, d- methadol, d -alpha ,acetylmethadol , l- alpha acetylmethadol d -alpha- normethadol, l -alpha -normethadol , pharmaceutically acceptable salts thereof, or mixtures thereof , to the subject under conditions effective for the substance to bind to the NMDA receptor and NE receptor of the subject.