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Globo H and related anti-cancer vaccines with novel glycolipid adjuvants
专利权人:
Chung-Yi Wu;Chi-Huey Wong;Alice L. Yu;John Yu
发明人:
Chi-Huey Wong,Chung-Yi Wu,Alice L. Yu,John Yu
申请号:
US12537129
公开号:
US08268969B2
申请日:
2009.08.06
申请国别(地区):
US
年份:
2012
代理人:
摘要:
Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CD1d on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM197.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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