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ФУНКЦИОНАЛИЗИРОВАННЫЕ ЛИПОСОМЫ, ПРИГОДНЫЕ ДЛЯ ДОСТАВКИ БИОАКТИВНЫХ СОЕДИНЕНИЙ
专利权人:
КОНСЕХО СУПЕРИОР ДЕ ИНВЕСТИГАСИОНЕС СЬЕНТИФИКАС (КСИС) (ES)
发明人:
ВЕНТОСА РУЛЛ Леонор (ES),ВЕСИАНА МИРО Хауме (ES),КАБРЕРА ПУЙГ Ингрид (ES),ЭЛИСОНДО САЭС ДЕ ВИКУНА Элиса (ES),МЕЛЬГАРЕХО ДИАС Марта (ES),РОЙО ЭКСПОЗИТО Мириам (ES),АЛЬБЕРИСИО ПАЛОМЕРА Фернандо (ES),ПУЛ
申请号:
RU2015102810
公开号:
RU2015102810A
申请日:
2013.06.28
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A conjugate comprising: i) a sterol ii) polyethylene glycol chain having a proximal end and a distal end, wherein said polyethylene glycol chain is covalently linked to its proximal end with i) by alkyl ester type connection iii) directing ligand capable of selective binding to one or more receptors, represented on a target cell, wherein said directing ligand is covalently linked to the distal ii) .2 end. The conjugate according to Claim. 1, wherein the sterol is holesterinom.3. The conjugate according to Claim. 1, wherein the polyethylene glycol chain has a number of repetitions from 2 to 10.4. The conjugate according to Claim. 1, wherein the guide is peptidom.5 ligand. The conjugate of claim. 4, wherein the guide comprises a ligand sequence RGD.6. . The conjugate of claim 5, wherein the directing ligand is the peptide sequence SEQ ID NO: 1.7. A liposome comprising the conjugate, as determined in Sec. 1.8. Liposome according to claim. 7 having a monomodal distribution chastits.9 size. Liposome according to claim. 8, wherein the average particle size is from 25 up to 500 nanometers, and the average potential Ζ absolute value of from 20 up to 90 mV.10. Liposome according to claim. 7, additionally comprising a therapeutic agent.11. The liposome of claim. 10 wherein the therapeutic agent is an α-galaktozidazoy.12. The method of delivery of a therapeutic agent, comprising administering the liposome of claim. 10.13. A method of treatment comprising administering a therapeutically effective amount of liposomes according to claim. 10, together with pharmaceutically acceptable excipients or carriers, to a subject in need of such treatment, including cheloveka.14. A method of treatment comprising administering a therapeutically effective amount of liposomes according to claim. 11, together with1. Конъюгат, содержащий:i) стеролii) цепь полиэтиленгликоля, имеющую проксимальный конец и дистальный конец, в котором указанная цепь полиэтиленгликоля ковалентно связана с ее прокс
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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