MCDONNELL, DONALD, P.,FRIGO, DANIEL,MEANS, ANTHONY, R.
申请号:
EP11818636
公开号:
EP2606130A4
申请日:
2011.08.16
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Provided herein are compounds, compositions, including pharmaceutical compositions, having anti-cancer activity. Also provided are methods for diagnosing, detecting, and treating cancer in a subject, as well as a method for evaluating cancer stage in a subject, wherein the methods include determining the amount of a Ca2+/calmodulin dependent kinase kinase (CaMKK) in a sample. Further provided are methods of screening and identifying a compound that inhibits CaMKK.