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תרכובות קרבוציקליות כמאפנני קולטן יתום קשור גמא
专利权人:
GLENMARK PHARMACEUTICALS S.A.
发明人:
申请号:
IL25752518
公开号:
IL257525D0
申请日:
2018.02.14
申请国别(地区):
IL
年份:
2018
代理人:
摘要:
The present disclosure is directed to novel carbocyclic compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, Ra, Rb, n, m and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, psoriasis, neurodegenerative diseases and cancer.
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