Ariadna Hernández Garcia;Norailys Lorenzo Perez;Ariana Barberá Betancourt;Vivian Morera Cordova;Nel;Carelia Cosme Diaz;Nelia López Marin;Gabriel Ramón Padrón Palomares;Maria del Carmen Domínguez Horta
发明人:
Maria del Carmen Domínguez Horta,Gabriel Ramón Padrón Palomares,Nelia López Marin,Norailys Lorenzo Perez,Ariana Barberá Betancourt,Ariadna Hernández Garcia,Vivian Morera Cordova,Carelia Cosme Diaz,Nel
申请号：
US12649687
公开号：
US08324164B2
申请日:
2009.12.30
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Peptides of human heat shock protein of 60 kDa, that constitute epitopes for T cells, as well as their derived peptides, which are modified at the contact sites with the MHC molecule, are useful to induce mechanisms of peripheral tolerance, in particular mechanisms of anergy or mediated by clones of regulatory T cells in patients with Rheumatoid Arthritis. The invention also refers pharmaceutical compositions comprising such peptides for the treatment of Rheumatoid Arthritis.
