Combination therapy comprising a MEK inhibitor, a PD-1 axis inhibitor and a VEGF inhibitor for the treatment of colorectal cancer and metastatic colorectal cancer is provided. [Selection] Figure 1結腸直腸がん及び転移性結腸直腸がんの治療のためのMEK阻害剤、PD-1軸阻害剤及びVEGF阻害剤を含む組合せ療法が提供される。【選択図】図1