Minatti, Ana Elena,Low, Jonathan D.,Allen, Jenifer R.,Chen, Jian,Chen, Ning,Cheng, Yuan,Judd, Ted,Liu, Qingyian,Lopez, Patricia,Qian, Wenyuan,Rumfelt, Shannon,Rzasa, Robert M.,Tamayo, Nuria A.,Xue, Qi
申请号：
AU2018204589
公开号：
AU2018204589A1
申请日:
2018.06.25
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018204589A120180712.pdf#####ABSTRACT The present invention provides a new class of compounds useful for the modulation of betasecretase enzyme (BACE) activity. The compounds have a general Formula (I): wherein variables A4, A5, A6, A8 , each of R1 and R2, R3 and R7 of Formula I, independently, are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to A-beta plaque formation and deposition, resulting from the biological activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, and sub-formula embodiments thereof, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.
