Systems, devices and methods are disclosed for reshaping airways concurrently with dental and/or orthodontic treatment. The systems can have a series of two or more oral appliances configured to progressively reposition the maxillary and mandibular teeth in two or more successive steps. Each oral appliance in the series can have one or more maxillary blocks, one or more mandibular blocks, a maxillary oral tray, and a mandibular oral tray. One or more maxillary blocks can be attached to or integrated with the maxillary oral tray. One or more mandibular blocks can be attached to or integrated with the mandibular oral tray. The maxillary and mandibular oral trays can be configured to move one or more teeth from a tooth first position to a tooth second position. The maxillary and mandibular blocks can be configured to interact with one another to treat sleep breathing disorders.
