A novel sorghum variety designated XSW4801 and seed, plants, plant parts and plant cells thereof are produced from a cross of inbred sorghum varieties. Methods for producing a sorghum plant comprise crossing hybrid sorghum variety XSW4801 with another sorghum plant. Sorghum variety XSW4801, the seed, the plant produced from the seed, and variants, mutants, and minor modifications of sorghum variety XSW4801 are provided. Methods for producing a sorghum plant containing in its genetic material one or more traits introgressed into sorghum variety XSW4801 include one or both of backcross conversion and transformation of one or both inbred parents. The sorghum seed, plants and plant parts produced thereby are described.