IMPAGLIAZZO, ANTONIETTA,MEIJBERG, JAN WILEM,RADOSEVIC, KATARINA,WAGNER, MICHELLE,DING, ZHAOQING
申请号：
PE2017000043
公开号：
PE20170291A1
申请日:
2015.07.09
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to polypeptides of stem domain of multi-element influenza blood cells, including at least one single blood cell domain and one single blood cell domain, Each single element includes: (a) the control area of Haemophilus influenzae type HA1, including the H1 trunk / terminal part which has the C trunk / terminal part at the same time with the HA1 trunk / terminal part； (b) the control area of Haemophilus influenzae type HA2, which is connected with the HA1 trunk / terminal part； (c) polyurethane does not include protein separation points in the alliance between the HA1 and HA2 domains； and (d) single elements are linked by disulfide bridges. These polypropylene are used for testingTreatment or prevention of influenzaSe refiere a polipeptidos de dominio de tallo de hemaglutinina de influenza multimericos que comprenden al menos un primer y un segundo monomeros de dicho dominio, donde cada monomero comprende: a) un dominio de hemaglutinina de influenza HA1 que comprende un segmento de tallo N-terminal de HA1 unido covalentemente a un segmento de tallo C-terminal de HA1； b) un dominio de hemaglutinina de influenza HA2 unido al segmento C-terminal de HA1； c) los polipeptidos no comprenden sitios de escision de proteasa en la union entre los dominios de HA1 y HA2； y d) los monomeros estan unidos mediante un puente disulfuro. Dichos polipeptidos son utiles en la deteccion, tratamiento o prevencion de la influenza
