This invention provides methods and compositions for using a live attenuated Listeria for inhibiting cell-mediated suppression of anti-disease infiltrating T lymphocytes in a subject having the disease.本發明提供使用活減毒李氏菌(Listeria)抑制患有疾病之個體中抗疾病浸潤性T淋巴細胞之細胞介導之抑制的方法及組合物。