Described are recombinant yeast comprising a nucleic acid sequence encoding human H-ferritin under the control of the yeast constitutive TDH3 transcriptional promoter, recombinant yeast comprising a nucleic acid sequence encoding human H- ferritin integrated into the yeast chromosome at the TDH3 site, H-ferritin expression cassettes for S. cerevisiae expressing human H-ferritin under the control of the yeast constitutive TDH3 transcriptional promoter, compositions comprising the recombinant yeast and their use in therapy, for example the treatment of iron disorders.
