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VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL BLOCKER
专利权人:
Nippon Chemiphar Co., Ltd.;Kinki University
发明人:
Hiroto TANAKA,Isao OOI,Yuzo MOGI,Masaaki HIROSE,Tsuyoshi ENDO,Toru OGAWA,Atsufumi KAWABATA
申请号:
US16069221
公开号:
US20190077767A1
申请日:
2017.01.12
申请国别(地区):
US
年份:
2019
代理人:
摘要:
A compound represented by the following General Formula (I), a tautomer or a stereoisomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof, is used as a voltage-dependent T-type calcium channel blocker:wherein A represents a fused ring which may have a substituent, the fused ring being composed of a 5-membered heteroaryl group or a 5-membered or 6-membered heterocyclic ring and a benzene ring or the like, the 5-membered heteroaryl group having one to three identical or different heteroatoms as a ring-constituting element(s) having at least one substituent such as an alkoxy group having 1 to 8 carbon atoms and substituted with 1 to 5 halogen atoms; R represents a hydrogen atom or the like; B represents CR5(Q1) or NQ2, herein Q1 represents a benzimidazole group which may have a substituent; Q2 represents an alkyl group having 1 to 8 carbon atoms which may have a substituent, a heteroaryl group which may have a substituent, or the like; R0, R1, R2, R3, R4, and R5 each represent a hydrogen atom or the like; and n and m each represent 0, 1, or 2, provide that n and m are not 0 and 2 at the same time.
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http://www.ckcest.cn/home/
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