The present invention can be used as the preventive medicine or medicine and its compound with uric acid excretion facilitation etc. of extremely related with serum uric acid value disease. The present invention relates to (azepine) indole derivatives indicated by following general formula (I), pro-drug or its salt, preventive medicine or medicine with xanthine oxidase inhibitory activity and as disease extremely related with serum uric acid value. In formula (I), T indicates nitro or cyano etc.； Ring J indicates aryl or heteroaryl etc.； Q indicates carboxyl or 5- tetrazole radicals etc.； Y indicates H, OH, NH2, halogen, nitro, alkyl, alkoxy etc.； X1, X2 and X3 independently indicate CR2 or N； R1 and R2 independently indicates halogen, and cyano, halogenated alkyl, A-D-E-G ,-N (- D-E-G) 2 etc., in formula, A indicates direct key, O, S etc.； D and G independently indicates optionally substituted alkylidene, cycloalkylidene, sub- Heterocyclylalkyl, arlydene, inferior heteroaryl etc.； E indicates direct key, O, S, COO, SO2 etc..本發明瞭可作爲與血清尿酸值異常有關的疾病的預防藥或治療藥並其具有尿酸排泄促進作用等等的化合物。本發明涉及由以下通式(I)表示的(氮雜)吲哚衍生物，其前體藥物，或其鹽，其具有黃嘌呤氧化酶抑制活性並且作爲與血清尿酸值異常有關的疾病的預防藥或治療藥。在式(I)中，T表示硝基或氰基等等；環J表示芳基或雜芳基等等；Q表示羧基或5-四唑基等等；Y表示H，OH，NH2，鹵素，硝基，烷基，烷氧基等等；X1，X2和X3獨立地表示CR2或N；R1和R2獨立地表示鹵素，氰基，鹵代烷基，A-D-E-G，-N(-D-E-G)2等等，在式中，A表示直接鍵，O，S等等；D和G獨立地表示任選被取代的亞烷基，亞環烷基，亞雜環烷基，亞芳基，亞雜芳基等等；E表示直接鍵，O，S，COO，SO2等等。
