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Wap domain fusion polypeptides and methods of use thereof
专利权人:
INHIBRX LLC
发明人:
CHAN HENRY,DEVERAUX QUINN,ECKELMAN BRENDAN P.,TIMMER JOHN C.,NGUY PETER L.,GUENTHER GRANT B.
申请号:
NZ61903512
公开号:
NZ619035A
申请日:
2012.06.28
申请国别(地区):
NZ
年份:
2015
代理人:
摘要:
Disclosed is an isolated fusion protein comprising at least one human whey acidic protein (WAP) domain-containing polypeptide comprising a human secretory leukocyte proteinase inhibitor (SLPI) polypeptide comprising the amino acid sequence of SEQ ID NO: 3 or a human elafin polypeptide comprising the amino acid sequence of SEQ ID NO: 6 operably linked to an immunoglobulin Fc polypeptide comprising an amino acid sequence that is at least 98% identical to the amino acid sequence of SEQ ID NO: 10, wherein the sequences are as listed in the complete specification.
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