A pressure assist system for facilitating vascular hemostasis includes a support bar and a midbar extending perpendicularly from a middle portion of the support bar, for supporting a users thumb when the user grasps the midbar. A base extends perpendicularly from a bottom of the support bar, for supporting the users knuckles when the user grasps the midbar. A foot for pressing against a wound is configured with a bottom surface of the base. The midbar may be adjustable along the support bar, according to user grip preference. In a related method, a hand-held pressure assist system is provided, having a support bar, a midbar and base extending perpendicularly from the support bar, and a foot beneath the base. A uses thumb and knuckles are positioned over the midbar and base, respectively. The foot is placed over a wound and downward pressure is applied until hemostasis is achieved.