A quantitative measurement system includes a quantitative imaging biomarker calibrator (116). The quantitative imaging biomarker calibrator (116) receives one or more pre-calibrated quantitative measurements of imaging data obtained according to a global features analysis (230) and a class-combination (232) of a biological target, an indicated biology, an imaging acquisition modality and a protocol, a data processing technique, and a contrast agent. The quantitative imaging biomarker calibrator (116) applies an identified function (234) to the one or more pre-calibrated quantitative measurements to compute the one or more calibrated quantitative measurements based on a target class-combination (236) which is different from the class-combination (232).
