CHUNG, IN HWAKR,정인화,LEE, IN KYUKR,이인규,MO, KIL WOONGKR,모길웅,HAN HAIZHUCN,한해수,HAN, GA RAMKR,한가람,KIM, HYEON JEONGKR,김현정,KIM, A REUMKR,김아름,JUNG, KI WONKR,정기원,AN, JI HUNKR,안지훈,CHUNG, IN HWA,LEE, IN KYU,MO, KIL WOONG,HAN HAIZHU,HAN, GA RAM,KIM, HYEON JEONG,KIM, A REUM,JUNG, KI WON,AN, JI HUN
申请号：
KR1020170044789
公开号：
KR1018330120000B1
申请日:
2017.04.06
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
The present inventors provide a pharmaceutical composition having a novel rotigotine form, and it was confirmed that the pharmaceutical composition as a novel crystalline dihydrate of rotigotine is excellent in stability during long-term refrigeration storage and the like, does not cause the transfer of a crystalline form during the refrigeration storage, has improved solubility, has the chemical formula weight of 351.46, a monoclinic system, P2(1), a=8.9818(4), b=13.8668(5), c=14.9591(6) and &beta；=90.8°；, and contains 10 to 14% of moisture.COPYRIGHT KIPO 2018본 발명자들은 로티고틴의 새로운 결정질 이수화물로서 냉장 장기 보관 등에서 안정성이 우수하며, 냉장보관 과정에서 결정형의 전이를 일으키지 않으며, 용해도가 개선된 화학식 중량 351.46, 단사정계, P2(1), a = 8.9818(4),b = 13.8668(5), c = 14.9591(6), β = 90.8°를 갖으며, 수분 10%에서 14%를 함유하는 새로운 이수화물 결정형을 포함한 약제학적 조성물을 제공한다.
