FUNG, SEK, CHUNG,MOYLE, MATTHEW,LU, MASON,YAN, CHANGNING,SINGH, SANJAYA,HUANG, DAN
申请号：
DK04815562
公开号：
DK1703893T3
申请日:
2004.12.23
申请国别(地区):
DK
年份:
2012
代理人:
摘要：
The present invention relates to anti-IL13 antibodies that bind specifically and with high affinity to both glycosylated and non-glycosylated human IL13, does not bind mouse IL13, and neutralize human IL13 activity at an approximate molar ratio of 1:2 (MAb:IL13). The invention also relates to the use of these antibodies in the treatment of IL13-mediated diseases, such as allergic disease, including asthma, allergic asthma, non-allergic (intrinsic) asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, eczema, urticaria, food allergies, chronic obstructive pulmonary disease, ulcerative colitis, RSV infection, uveitis, scleroderma, and osteoporosis.
