PROBLEM TO BE SOLVED: To provide a lipid transporter protein: ABCA12 gene expression promoter, which is novel and useful and plays an important role in maintaining lipid homeostasis. The ABCA12 gene expression promoter can be used as a drug expected to maintain lipid homeostasis by preventing hyperkeratosis of the epidermis and gastric mucosa caused by a decrease in various internal and external factors. It is highly usable and can be used in a wide range of industries such as beverages, cosmetics and other external preparations as well as pharmaceuticals and foods (including foods and drinks that are beauty and health conscious). SOLUTION: An ABCA12 gene expression promoter containing a peony extract as an active ingredient. [Selection diagram] None【課題】本発明は、新規かつ有用であり、脂質恒常性維持に重要な役割を果たす脂質トランスポータータンパク質：ＡＢＣＡ１２遺伝子発現促進剤の提供を目的とする。ＡＢＣＡ１２遺伝子発現促進剤は、様々な内的・外的要因の低下によって生じる表皮や胃粘膜の過角化等を防止し、脂質恒常性維持を期待する薬剤として使用することができる。利用性が高く、医薬品、食品（美容や健康志向の飲食品を含む）のみならず、飲料、化粧料等外用剤といった産業上における広い範囲での利用が可能である。【解決手段】シャクヤク抽出物を有効成分とするＡＢＣＡ１２遺伝子発現促進剤。【選択図】なし
