Stevens, Sean,Wang, Li-Hsien,Martin, Joel H.,Allison, Erin M.
申请号:
AU2008282152
公开号:
AU2008282152B2
申请日:
2008.07.31
申请国别(地区):
AU
年份:
2013
代理人:
摘要:
A human antibody or antigen-binding fragment of an antibody that specificallybinds human CD20 and is capable of inducing complement dependent cytotoxicity(CDC), and is capable of increasing symptom free survival time between about2-fold to about 9-fold or more, relative to control-treated animals in a mousemodel of human lymphoma. The antibody or antigen-binding fragment thereof isuseful in a therapeutic method for treating a CD20-mediated disease or condition,such as for example, non-Hodgkin's lymphoma, rheumatoid arthritis, systemiclupus erythematosus, Crohn's disease, chronic lymphocytic leukemia,and inflammatory diseases.