According to one embodiment of a management system for damage risk of tissue pressure, at least one pressure sensor is deployed on at least one pressure-withstanding location on a body surface of a user, and detects a plurality of extremity pressure signals from the at least a pressure-withstanding location. An information processing device uses the plurality of extremity pressure signals to compute and store at least one risk assessment index, uses a plurality of features of the plurality of extremity pressure signals to compute at least one risk adjustment factor, and then uses the at least one risk adjustment factor to calibrate the at least one risk assessment index.