Double-stranded nucleic acid inhibitor molecules modified with Tm-increasing nucleotides

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专利权人:

Dicerna Pharmaceuticals; Inc.

发明人:

WANG, Weimin,NAZEF, Naim,BROWN, Bob Dale

申请号：

AU2019252529

公开号：

AU2019252529A1

申请日:

2019.04.11

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

Provided herein are double-stranded nucleic acid inhibitor molecules having a sense strand with a stem loop structure and an antisense strand, where the stem portion of the stem loop structure contains one or more Tm-increasing nucleotides. Also provided are methods and compositions for reducing target gene expression and methods and compositions for treating a disease of interest.

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中国工程科技知识中心

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http://www.ckcest.cn/home/