The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides.本發明係關於調節α-ENaC表現的組合物及方法,更特別關於藉由化學修飾之寡核苷酸來下調α-ENaC表現。